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The aim of the MAPEG 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants:
For this purpose, we want to compare the results of the following tests:
Identifying and following the evolution of early taste disorders in case of cognitive disorders could improve the diagnosis of Alzheimer's disease in two ways:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control subjects | Active Comparator |
| |
| Subjects with an isolated cognitive complaint | Experimental |
| |
| Subjects with minor neurocognitive disorders | Experimental |
| |
| Subjects with major neurocognitive disorders of the mild to moderate Alzheimer's disease type | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood samples | Biological | Fasting at the first session for hormonal measurements of leptin, insulin, acylated and non-acylated ghrelin, serotonin, albumin, protidemia and blood glucose. Repeated at 6 and 12 months for follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Amplitude of the gustatory evoked potentials | After a 2-hour fasting period | |
| Gustatory evoked potentials latency | After a 2-hour fasting period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Agnès JACQUIN-PIQUES | Contact | 03.80.29.37.54 | agnes.jacquin-piques@chu-dijon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon Bourgogne | Recruiting | Dijon | France |
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| Interviewing the subject and scales | Other | Collection of sociodemographic data, personal and family neurological history, treatments, MADRS depression scale and CDR autonomy scale. Carried out at the 1st session |
|
| Neurocognitive evaluation | Other | cognitive complaint questionnaire (CCQ), taste, smell, MoCA and MMSE (if not performed in the previous 6 months) Carried out at the 1st session. Repeated at 6 and 12 months for follow-up. |
|
| Taste tests | Other | Sweet and salty flavors at the 1st session and acid and umami flavors at the 2nd session. Repeated at 6 and 12 months for follow-up. Placement of electrodes on the scalp, recording of gustatory evoked potentials, subjective gustatory evaluation by means of visual analogue scales rated from 0 to 10, identification and naming of each of the primary flavors |
|
| Computerized food preference questionnaires | Other | Performed at the 1st session on a tactile tablet. Repeated at 6 and 12 months for follow-up. |
|
| Nutritional status - body composition | Other | Measurement of anthropometric data, bioelectrical impedancemetry (measurement of fat mass, lean mass, water mass and bone mass in kg), measurement of blood pressure and heart rate Performed at the 2nd session Repeated at 6 and 12 months for follow-up. |
|
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D014894 | Weights and Measures |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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