Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Patients with retinal detachment are at risk of recurrence and failure of surgery requiring multiple surgeries due to a condition called proliferative vitreoretinopathy (PVR).
Study aims to help tailor patients' treatments and improve outcomes by:
[i] studying imaging biomarkers of PVR, and [ii] develop AI models for PVR detection.
Inclusion:
Non -invasive multimodal imaging and anonymized imaging will be used to study imaging biomarkers of PVR and develop deep learning models to predict PVR in collaboration with an artificial intelligence (AI) expert team at UCL Institute of Ophthalmology.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rhegmatogenous retinal detachment without proliferative vitreoretinopathy | Rhegmatogenous retinal detachment without proliferative vitreoretinopathy at the time of their primary surgery | ||
| Rhegmatogenous retinal detachment with proliferative vitreoretinopathy | Rhegmatogenous retinal detachment with proliferative vitreoretinopathy at the time of their primary surgery or post-operatively with recurrent retinal detachment. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| To study multimodal imaging biomarkers of PVR. | Use multimodal imaging namely widefield Optos, Widefield OCT, OCT macula, OCT disc, OCT EDI and OCTA to describe biomarkers of PVR. | Preoperative biomarkers of PVR on cases with established PVR Post-operative biomarkers of PVR on cases that develop PVR in the first 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| To develop deep learning AI models for PVR detection in retinal detachment. | Use widefield Optos imaging and OCT to:
| Post-operative 3 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
MORPH-1 - PVR detachments Cohort-NHS - primary RRD without PVR requiring PPV with PVD.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| James Bainbridge | University College, London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University College London | London | United Kingdom |
Within participant's consent.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D018630 | Vitreoretinopathy, Proliferative |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided