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The aim of the study is to identify morphological and functional biomarkers of post-operative recovery after vitreoretinal surgery, using decisional support systems (DSS), based on multimodal big-data analysis by means of machine learning techniques in daily clinical practice
The aim of the study is to identify morphological and functional biomarkers of post-operative recovery after vitreoretinal surgery. Identifying the biomarkers and assessing the predictivity of recovery will make it possible to highlight the categories of patients who can benefit most from surgical treatment, and to target the patient more precisely for personalised medicine and surgery. The introduction of new decisional support systems (DSS), based on multimodal big-data analysis through machine learning techniques in daily clinical practice, is providing new useful information in patient assessment for personalised surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Macular hole | Patients affected by macular hole. |
| |
| Epiretinal membranes | Patients affected by epiretinal membrane. |
| |
| Retinal detachment | Patients affected by retinal detachment. |
| |
| Macular dystrophies | Patients affected by macular dystrophies. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biometry | Diagnostic Test | Biometric measurements performed with IOL Master, if executable Contact or immersion echobiometry if IOL Master cannot be performed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Predictivity of morphological-functional radiomic data | Rate of predictivity of morphological-functional radiomic data to establish the grade of recovery in the post-operative period by means of an artificial intelligence (AI) machine learning model. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Identify predictive differences according to diagnosis | Subdivision into subgroups in order to identify predictive differences according to diagnosis | 3 years |
| Correlating with the age of patients |
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Inclusion Criteria:
All patients to undergo vitreo-retinal surgery for:
Exclusion Criteria:
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All patients to undergo vitreo-retinal surgery for macular disease (i.e.Macular hole, epiretinal membranes, Retinal detachment, Macular dystrophies (retinal pre-prosthesis).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maria Cristina Savastano, MD,PhD | Contact | +39 3384443002 | mariacristina.savastano@unicatt.it | |
| Alfonso Savastano, MD,PhD | Contact | alfonso.savastano@policlinicogemelli.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prof. Stanislao Rizzo | Recruiting | Rome | 00168 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| Retinography (Color) + Autofluorescence (AF) | Diagnostic Test | Colour + AF: EIDON, if available (60° not modulable) Colour: COBRA (60° non-modifiable) AF: Spectralis-Heidelberg (choose 55°) Other if available (choose posterior pole examination between 50-60°) |
|
| OCT B-scan and OCT angiography (OCTA) | Diagnostic Test | OCT B-scan: 2 scans (6 mm) 1 cross line OCTA: 3x3 mm + 6x6 mm centred on the fovea 4.5 mm centred on the optic nerve |
|
| Microperimetry | Diagnostic Test | 1) fixation pattern 2) retinal sensitivity map |
|
| Electrophysiological exams | Diagnostic Test | Layer-by-layer assessment of the retina using focal ERG and pattern ERG according to standardised and published methods , For patients with visus < 3/10 and unstable fixation a protocol based on component analysis of the photopic ERG from diffuse flash will be used. |
|
Identify predictive differences according to diagnosis and correlate them with the age of patients
| 3 years |
| Correlate with age of onset of disease | Identify predictive differences according to diagnosis and correlate them with the age of onset of disease | 3 years |
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| ID | Term |
|---|---|
| D012167 | Retinal Perforations |
| D019773 | Epiretinal Membrane |
| D012163 | Retinal Detachment |
| D008268 | Macular Degeneration |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D012162 | Retinal Degeneration |
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| ID | Term |
|---|---|
| D003116 | Color |
| ID | Term |
|---|---|
| D008027 | Light |
| D055620 | Optical Phenomena |
| D055585 | Physical Phenomena |
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