The purpose of this prospective, longitudinal, single-center observational study is to identify, describe, and measure the morpho-functional characteristics and modifications of the retina and choroid using advanced multimodal imaging techniques. The study will evaluate patients affected by retino-choroidal diseases and compare them with healthy controls over a 5-year follow-up period to track the evolution of these parameters over time.

Inclusion Criteria:

• freely given informed consent acquired prior to the start of the study.
• Participant's capacity to understand the informed consent and study procedures.
• Age ≥ 6 years (with parental/guardian consent for minors).
• Patients affected by any retino-choroidal disease.
• Healthy subjects showing no retino-choroidal pathology.

Exclusion Criteria:

• Patient unable and/or unwilling to cooperate.
• Presence of media opacities (dioptric media) that prevent image acquisition or significantly reduce the quality of the obtained images.

The study population consists of both healthy volunteers and patients diagnosed with any type of retino-choroidal pathology. Participants will be selected from individuals who routinely attend or are referred to the outpatient clinics at the IRCCS Fondazione G. B. Bietti in Rome, Italy. The sample is designed to include a wide age range (age ≥ 6 years old) to capture the natural progression and morpho-functional characteristics of these conditions across different demographics. The cohort will feature a 4:1 allocation ratio, comprising 100 patients with retino-choroidal diseases and 25 age- and sex-matched healthy controls to ensure adequate statistical power for longitudinal progression analysis.