Several optical coherence tomography (OCT) biomarkers with potential to influence postsurgical outcomes after vitrectomy with membrane peeling for idiopathic epiretinal membranes (iERM) have been described in single predictor analyses in the past. Aim of the study is to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity in a multiple regression analysis.

Several optical coherence tomography (OCT) biomarkers with potential to influence postsurgical outcomes after vitrectomy with membrane peeling for idiopathic epiretinal membranes (iERM) have been described in single predictor analyses in the past. A recent multifactorial analysis outlined macular thickness and DRIL to be significant predictors for postsurgical visual acuity (Karasavviodou et al.). Nevertheless, reliability of diagnosing OCT biomarkes among patients with iERM was not yet assessed, to our knowledge. Aim of the study is to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity in a multiple regression analysis.

Inclusion Criteria:

• a) presence of an iERM,
• b) indication for membrane peeling, defined as significant loss of visual acuity and/or metamorphopsia due to the ERM,
• c) pseudophakia at the final visit at 3 months after surgery, and
• d) written informed consent for study participation.

Exclusion Criteria:

• macular edema caused by conditions other than ERM were excluded from the study.

Patients with iERM sheduled for vitrectomy with membrane peeling.