Beta3-adrenergic Receptors and Cardiovascular Function in... | NCT07674680

Studies
Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

NCT07674680

Sponsor

University of Missouri-Columbia

Status

Not yet recruiting

Last Update Posted

Jun 29, 2026Actual

Enrollment

60Estimated

Phase

Early Phase 1

Conditions

Women
Aging
Menopause

Interventions

Placebo
Gemtesa

Countries

United States

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jun 2026

Overall Recruitment Status or Expanded Access Status

Not yet recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jul 2026Estimated

Primary Completion Date

May 2028Estimated

Completion Date

May 2029Estimated

First Submitted Date

Jun 17, 2026

First Submission Date that Met QC Criteria

Jun 23, 2026

First Posted Date

Jun 29, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jun 23, 2026

Last Update Posted Date

Jun 29, 2026Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Jacqueline K Limberg, PhD, Associate Professor, University of Missouri-ColumbiaPrincipal Investigator

Lead Sponsor

University of Missouri-ColumbiaOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Yes

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

FDAAA801 Violation

Not provided

Description Module

Brief Summary

We hypothesize vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

Detailed Description

Not provided

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Early Phase 1

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

60Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Cold pressor test	Experimental	Participants will be exposed to the cold pressor test (ice water on the foot).	Drug: Placebo Drug: Gemtesa
Flow Mediated Dilation	Experimental	Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.	Drug: Placebo Drug: Gemtesa

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Placebo	Drug	Participants will receive a placebo in pill form.	Cold pressor test Flow Mediated Dilation

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Blood flow	Blood flow measured with Doppler ultrasound.	Change from baseline to minute 2.

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Healthy women Assigned female at birth 18-70 years of age Body mass index <18 or ≥30 kg/m2

Exclusion Criteria:

Assigned male at birth Pregnancy Breastfeeding History of hormone replacement therapy, chemical menopause, or oophor-ectomy Polycystic ovarian syndrome or Primary ovarian insufficiency Current smoking/Nicotine use Blood pressure ≥140/90 mmHg Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy Nerve/neurologic disease Cardiovascular, hepatic, renal, respiratory disease Hypersensitivity to nitroglycerin Diabetes Communication barriers

Accepts Healthy Volunteers

Yes

Sex

Female

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

70 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Jacqueline Limberg Associate Professor	Contact	1-573-882-2544		limberglab@missouri.edu

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
University of Missouri		Columbia	Missouri	65211	United States

IPD Sharing Statement Module

Plan to Share IPD

Undecided

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided