Early Neurovascular Adaptations in Aging Women | NCT06520982

Studies
Early Neurovascular Adaptations in Aging Women

NCT06520982

Sponsor

University of Missouri-Columbia

Status

Recruiting

Last Update Posted

Nov 26, 2025Actual

Enrollment

64Estimated

Phase

Early Phase 1

Conditions

Women
Sympathetic Nervous System
Aging
Blood Flow

Interventions

Norepinephrine
Isoproterenol
Acetylcholine
Nitroprusside
Estrogen

Countries

United States

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Nov 2025

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Sep 20, 2024Actual

Primary Completion Date

Jun 30, 2027Estimated

Completion Date

Jun 30, 2028Estimated

First Submitted Date

Jul 22, 2024

First Submission Date that Met QC Criteria

Jul 22, 2024

First Posted Date

Jul 25, 2024Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Nov 20, 2025

Last Update Posted Date

Nov 26, 2025Actual

Name	Class
American Heart Association	OTHER

Oversight Module

Has Data Monitoring Committee (DMC)

Not provided

Is FDA Regulated Drug

Yes

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Detailed Description

Not provided

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Early Phase 1

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

64Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Women	Other	Women will be 18-70 years of age	Drug: Norepinephrine Drug: Isoproterenol Drug: Acetylcholine Drug: Nitroprusside Drug: Estrogen

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Norepinephrine	Drug	Infused intra-arterially in a dose-response fashion	Women

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Magnitude of forearm blood flow		Change from baseline during infusion

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Assigned female at birth (AFAB)
18-70 years of age

Exclusion Criteria:

Assigned male at birth (AMAB)
Pregnancy, breastfeeding
Body mass index ≥30 kg/m2
Taking medications known to affect metabolic, autonomic, and/or respiratory function
Oral hormonal contraception in last 6 month
History of hormone replacement therapy
History of hyster- or oophor-ectomy
Current smoking/Nicotine use
Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
Chronic disease
Blood pressure ≥140/90 mmHg
Communication barriers

Accepts Healthy Volunteers

Yes

Sex

Female

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

70 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Jacqueline K Limberg	Contact	573-882-2420		limbergj@missouri.edu

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
University of Missouri-Columbia	Recruiting	Columbia	Missouri	65211	United States

IPD Sharing Statement Module

Plan to Share IPD

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D009638	Norepinephrine
D007545	Isoproterenol
D000109	Acetylcholine
D009599	Nitroprusside
D004967	Estrogens

Ancestor Terms

ID	Term
D004983	Ethanolamines
D000605	Amino Alcohols
D000438	Alcohols
D009930	Organic Chemicals

Browse Leaves

Not provided

Browse Branches

Not provided