NCMT Technique and Jodhpur Technique and Excimer Laser in Treatment of Non Vitiligo Leucoderma

Efficacy and Safety of Melanocyte Keratinocyte Transplantation Procedure Plus 308-nm Excimer Laser in the Treatment of Non-Vitiligo Leukoderma

This study aims to compare the efficacy and safety of Melanocyte Keratinocyte Transplantation Procedure (MKTP) combined with 308-nm excimer laser versus Jodhpur technique combined with 308-nm excimer laser in the treatment of stable non-vitiligo leukoderma. Twenty-two patients with stable depigmented lesions will be enrolled. In each patient, two comparable lesions will be treated using different techniques. Clinical outcomes including percentage of repigmentation, color match, time to onset of repigmentation, complications, and histological changes will be assessed during follow-up to determine the optimal surgical treatment approach for non-vitiligo leukoderma.

Inclusion Criteria:

• Age 18 to 60 years.
• Clinically diagnosed stable non-vitiligo leukoderma.
• Stable lesion(s) for at least 6 months with no progression.
• Inadequate response to conventional medical therapy.
• Presence of two comparable lesions
• Willingness to participate and provide written informed consent.

Exclusion Criteria:

• Vitiligo or suspected active vitiligo.
• History of keloid or hypertrophic scar formation.
• Active infection at donor or recipient sites.
• Bleeding disorders or anticoagulant therapy that cannot be safely discontinued.
• Pregnancy or lactation.
• Immunosuppression or uncontrolled systemic disease.
• Inability to comply with follow-up visits.
• Unrealistic expectations regarding treatment outcome.