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In vitiligo, the melanocytes are lost from the skin in certain areas. One treatment for vitiligo takes the melanocytes from areas of normal skin and places them on areas of that same person's body which have lost their color. This is called the melanocyte-keratinocyte transplantation procedure (MKTP). This procedure has been used successfully in over 3000 cases in India and Saudi Arabia. The purpose of this study is to see if it is effective when performed at the investigators' institution.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MKTP treatment | Experimental | subject will undergo MKTP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Melanocyte-keratinocyte transplantation procedure (MKTP) | Procedure | skin pigment cells are taken from areas of normal skin and placed on areas of that same person's body which have lost their color. |
| Measure | Description | Time Frame |
|---|---|---|
| effectiveness of MKTP in treating vitiligo | Assessed by percent repigmentation (excellent= 100%-95%, good= 94%-65%, fair= 64%-25%, poor= 24%-0%). | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| safety of MKTP in treating vitiligo | Assessed by frequency of adverse events, including, scarring, infection, etc. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Iltefat H Hamzavi, MD | Henry Ford Health Systems Dermatology Department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Henry Ford Medical Center, New Center One | Detroit | Michigan | 48202 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15492183 | Background | Mulekar SV. Long-term follow-up study of segmental and focal vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation. Arch Dermatol. 2004 Oct;140(10):1211-5. doi: 10.1001/archderm.140.10.1211. | |
| 16207186 | Background | Mulekar SV. Long-term follow-up study of 142 patients with vitiligo vulgaris treated by autologous, non-cultured melanocyte-keratinocyte cell transplantation. Int J Dermatol. 2005 Oct;44(10):841-5. doi: 10.1111/j.1365-4632.2005.02226.x. |
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| ID | Term |
|---|---|
| D014820 | Vitiligo |
| ID | Term |
|---|---|
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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