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This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients. The study evaluates whether brief, non-interactive VR sessions delivered using a commercially available standalone head-mounted display with calming, nature-based content can be delivered safely and effectively within routine SICU workflow. Exploratory objectives assess whether VR sessions are associated with changes in anxiety, agitation, delirium, pain, and sedative medication requirements. This research is not intended to evaluate the safety or effectiveness of the headset and/or the specific VR software used for the research
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VR Intervention | Experimental | Critically ill patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Virtual reality (VR) therapy | Behavioral | VR sessions will use a commercially available headset with non-interactive, immersive content displaying calming nature-based content (e.g., ocean/beach scenes, forests, mountains) delivered through a commercially available VR application |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of Intervention Measure (FIM) | From time of enrollment to end of intervention at 3 days | |
| Acceptability of Intervention Measure (AIM) | From time of enrollment to end of intervention at 3 days | |
| Intervention Appropriateness Measure (IAM) | From time of enrollment to end of intervention at 3 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pauline H Go, MD | Contact | 717-531-5429 | paulinego@pennstatehealth.psu.edu | |
| Aleksandr Davtyan | Contact | adavtyan@pennstatehealth.psu.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State Milton S. Hershey Medical Center | Recruiting | Hershey | Pennsylvania | 17033 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35172527 | Background | Haley AC, Wacker DA. Cinematic virtual reality for anxiety management in mechanically ventilated patients: a feasibility and pilot study. Acute Crit Care. 2022 May;37(2):230-236. doi: 10.4266/acc.2021.00843. Epub 2022 Feb 4. | |
| 39046869 | Background | Locke BW, Tsai TY, Reategui-Rivera CM, Gabriel AS, Smiley A, Finkelstein J. Immersive Virtual Reality Use in Medical Intensive Care: Mixed Methods Feasibility Study. JMIR Serious Games. 2024 Aug 9;12:e62842. doi: 10.2196/62842. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | May 6, 2026 | Jun 10, 2026 |
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|
| 33648572 | Background | Naef AC, Jeitziner MM, Gerber SM, Jenni-Moser B, Muri RM, Jakob SM, Nef T, Hanggi M. Virtual reality stimulation to reduce the incidence of delirium in critically ill patients: study protocol for a randomized clinical trial. Trials. 2021 Mar 1;22(1):174. doi: 10.1186/s13063-021-05090-2. |
| 32695991 | Background | Ong TL, Ruppert MM, Akbar M, Rashidi P, Ozrazgat-Baslanti T, Bihorac A, Suvajdzic M. Improving the Intensive Care Patient Experience With Virtual Reality-A Feasibility Study. Crit Care Explor. 2020 Jun 8;2(6):e0122. doi: 10.1097/CCE.0000000000000122. eCollection 2020 Jun. |
| 34217986 | Background | Jawed YT, Golovyan D, Lopez D, Khan SH, Wang S, Freund C, Imran S, Hameed UB, Smith JP, Kok L, Khan BA. Feasibility of a virtual reality intervention in the intensive care unit. Heart Lung. 2021 Nov-Dec;50(6):748-753. doi: 10.1016/j.hrtlng.2021.05.007. Epub 2021 Jul 1. |
| Prot_000.pdf |
| ID | Term |
|---|---|
| D010146 | Pain |
| D011595 | Psychomotor Agitation |
| D001008 | Anxiety Disorders |
| D007319 | Sleep Initiation and Maintenance Disorders |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020820 | Dyskinesias |
| D009422 | Nervous System Diseases |
| D011596 | Psychomotor Disorders |
| D019954 | Neurobehavioral Manifestations |
| D000096762 | Aberrant Motor Behavior in Dementia |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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