The goal of this clinical trial is to learn the effect of Virtual Reality Family Support System (VRFS) on reducing delirium in ICU mechanically ventilated patients. The main question it aims to answer is:

·Using VRFS for participant intervention, can it reduce the incidence of delirium and improve clinical outcomes?

Researchers will investigate whether the implementation of VRFS can reduce the number of delirium days and improve clinical outcomes.

Participants will:

• Receive the VRFS intervention until the endotracheal tube (ETT) is removed.
• Have physiological data collected, including EEG, oxygen saturation levels, ECG, and blood pressure.
• Keep a diary of delirium, dosage of sedative and analgesic drugs, the duration of mechanical ventilation, and ICU stays.

During the VRFS interventions, researchers will fit participants with a VR headset and noise-canceling headphones, shielding them from the ICU environment while allowing family members to be present and offer companionship and comfort.

Inclusion Criteria

• Mechanical ventilation duration is expected to be greater than 24 hours;
• ICU stay duration is expected to be greater than 72 hours;
• Age is 18 years or older, with no upper age limit;
• Language: Chinese. Exclusion Criteria
• Severe visual or auditory impairments (diplopia, low vision due to macular degeneration, retinopathy; severe hearing loss or deafness);
• Cognitive and consciousness disturbances prior to ICU admission;
• Severe motion sickness;
• Head trauma or surgery that prevents the wearing of equipment;
• A history of long-term use of antipsychotic and/or benzodiazepine medications.

Due to the nature of the VR intervention, blinding of participants and care providers is not feasible. Outcome assessors (nurses responsible for delirium assessment using CAM-ICU) are blinded to group allocation and are not involved in the delivery of the intervention.