Letrozole Plus Misoprostol Versus Misoprostol Only in Induction of Missed Abortion

Letrozole Plus Misoprostol Versus Misoprostol Only in Induction of Missed Abortion: A Randomized Controlled Trial

This study aimed to evaluate the effect of letrozole plus misoprostol to terminate non-viable pregnancies in first trimester compared with the use of misoprostol alone.

Inducing abortion by drugs is an alternative for surgery intervention, which has economic benefits with lower side effects and its rate of success is 60 to 95%.

Letrozole is also one of aromatase inhibitors, which is used to stimulate ovulation in infertile women suffering ovulatory dysfunction. This drug is one of the main drugs for inhibiting aromatase, with a relatively short 45-hour half life, which is active orally and inhibits aromatase enzyme reversibly.

Misoprostol is a relatively safe drug and of its side effects it is possible to mention to gestational effects, feeling of warmth, and shivering. Severe side effects of misoprostol consumption are severe bleeding and endometritis, with less than 1% prevalence based on studies.

Inclusion Criteria:

• Age from 18 to 45 years.
• Women with nonviable pregnancies undergoing 1st-trimester abortion.

Exclusion Criteria:

• Medical diseases like renal or liver disease.
• Severe bleeding and shocked patients.
• Inevitable abortion.
• Hypersensitivity to any of the drugs.