Letrozole Pretreatment With Misoprostol Induction of Abortion in First Trimester Missed Abortion

Use of Letrozole Pretreatment With Misoprostol for Induction of Abortion in First Trimester Missed Abortion

this study will compare the efficacy of using letrozole pre treatment before misoprostol versus using misoprostol only in the induction of first trimester missed abortion.

Intervention type: drug

Intervention name: letrozole then misoprostol

Description :letrozole 2.5mg twice per day for 2days then misoprostol 800mcg for all patients to induce abortion

Arm group label:study group

Intervention type :drug

Intervention name:placebo then misoprostol

Description : placebo for 2days then 800mcg misoprostol to all patients to induce abortion

Arm group label: control group

Inclusion Criteria:

1. Maternal age more than 18 years old.
2. Gestational age less than 13 weeks confirmed by ultrasound scan on day 1 of the study.
3. Hemoglobin >10 g/dl
4. Missed abortion

Exclusion Criteria:

1. Mullerian Uterine anomalies as septate, bicornuate uterus.

2. Fibroid uterus.

3. Coagulopathy.

4. Medical disorder that contraindicate induction of abortion.

5. Allergy to misoprostol or letrozole.

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