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This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group | Experimental | 3 tablets of Letrozole 2.5 mg will be given as single daily dose, 7.5 mg per day for two days at home and the third dose will be given on admission to hospital on day 3 and will be followed by vaginal misoprostol 800 mcg every three hours up to maximum two doses. |
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| control group | Placebo Comparator | three tablets of placebo will be given as a single daily dose, for two days at home and will be admitted on day 3 and continue treatment with misoprostol 800 mcg every three hours up to maximum two doses |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| letrozole then misoprostol | Drug | Drug: Letrozole 2.5mg total dose 7.5 mg per day for 3 days Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion |
| Measure | Description | Time Frame |
|---|---|---|
| induction to abortion time | induction to abortion time | 6 hours |
| Incidence of complete miscarriage | Incidence of complete miscarriage | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Need for surgical evacuation of the products of conception | Need for surgical evacuation of the products of conception | 6 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| AHMED SAMY | Contact | +201100681167 | ahmedsamy8233@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| AHMED SAMY | Cairo University | Principal Investigator |
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| ID | Term |
|---|---|
| D000030 | Abortion, Missed |
| ID | Term |
|---|---|
| D000022 | Abortion, Spontaneous |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| placebo then misoprostol | Drug | Drug: Placebo placebo for 3 days Drug: Misoprostol Misoprosrol 800mcg will be given to all patients for induction of abortion |
|