Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Chalmers University of Technology | OTHER |
| Karolinska Institutet | OTHER |
Not provided
Not provided
Not provided
Not provided
Ultra-processed food (UPF) intake has been related to negative health effects and incresed energy intake in previous intervention studies. Thus, previous studies have seen weight gain from higher UPF intake which obscures the potentital to see effects on cardiometabolic biomarkers, independent of weight changes. The overall aim of this project is to study the causal effects of a high UPF diet, compared to a nutrient-matched low UPF diet, on appetite and cardiometabolic health in a weight-stable context.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence 1: high UPF, low UPF | Experimental | Diet high in UPF, followed by a diet low in UPF |
|
| Sequence 2: low UPF, high UPF | Experimental | Diet low in UPF, followed by a diet high in UPF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diet high in UPF | Other | Diet high in Ultra-processed food (>80 % of total energy intake) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Leptin | Change from baseline to 6 weeks | |
| ApoB | Apolipoprotein B | Change from baseline to 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Leptin | Change from baseline to 2 weeks | |
| ApoB | Apolipoprotein B | Change from baseline to 2 weeks |
| Ghrelin, PYY, cholecystokinin, insulin |
| Measure | Description | Time Frame |
|---|---|---|
| Oral microbiome | Change in oral microbial composition | At 2 weeks and 6 weeks |
| Compliance | Compliance assessed by food records | At 2 weeks and 6 weeks |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Linnea Bärebring, PhD, Associate professor | Contact | 0317863771 | +46 | linnea.barebring@gu.se |
| Therese Karlsson, PhD, Associate professor | Contact | therese.karlsson@gu.se |
| Name | Affiliation | Role |
|---|---|---|
| Linnea Bärebring, PhD, Associate professor | Göteborg University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Gothenburg | Gothenburg | 40530 | Sweden |
Ethical approvals and legal issues must be considered and resolved before data of individuals can be shared.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Those conducting laboratory analyses will be blinded to the allocation of participants.
Not provided
| Diet low in UPF | Other | Diet low in Ultra-processed food (<20 % of total energy intake) |
|
Other appetite-regulating hormones |
| Change from baseline to 2 weeks and from baseline to 6 weeks |
| Blood lipid profile | ApoA1, LDL, HDL, VLDL, total cholesterol, triglycerides, Lp(a) | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Body weight | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Body composition | Fat mass and fat-free mass | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Blood pressure | Diastolic and systolic blood pressure | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Biomarkers of ultra-processed food intake | Measured in blood and urine | At 2 weeks and at 6 weeks |
| Gut microbiome | Change in gut microbial composition and diversity (alpha- and beta) | At 2 weeks and 6 weeks |
| Glucose | Glucose, measured by continuous blood glucose monitoring | Continuous during the first 2 weeks |
| Energy intake | Ad libitum energy intake at standardized test meal | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Subjective appetite | Self-rated appetite before and after a standasized test meal | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Food cravings and eating behavior | Control of Eating Questionnaire, Three Factor Eating Questionnaire, Power of Food Scale | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Sleep | Pittsburgh Sleep Quality Index | Change from baseline to 2 weeks and from baseline to 6 weeks |
| Well-being | WHO-5 Wellbeing Index | Change from baseline to 2 weeks and from baseline to 6 weeks |