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To collect data, written consent was obtained from the hospital and university administration. After receiving signed informed consent, the data was collected from cardiac patients.
The target population was adults between the ages of 35 and 65 years who were receiving outpatient care at a hospital or clinic with a diagnosis of either mild to moderate hypertension, mild to moderate alterations in lipid profile or pre-diabetes. To select potential participants from the study population, subjects with a medical history of diabetes, measuring fasting blood glucose, lipid profile and blood pressure were screened.Following screening, participants were divided evenly into three groups: experimental group (1, 2) and one control group. The participants were advised to take 2 slices of bread in breakfast. Individualized plans were given according to their nutrient requirements. A systematic communication plan was developed in order to follow up with participants on their daily consumption of the suggested watermelon rind-based bread through telephonic conversations. For continuous assistance there was a WhatsApp group set up where members may ask issues and get help. The follow up for patients were conducted every month; baseline and after 6 pre-treatments. Appointments for follow-up exams were done after every 15 days in order to track developments, anthropometric measurements were calculated every follow up and modify the dosage as necessary. The baseline and post study test was compared to test the hypothesis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group on whole wheat bread | Placebo Comparator | Participants were only subjected to use Wheat bread in breakfast. |
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| G1 on 40% WRB | Experimental | Participants were advised to take Watermelon rind-based bread (40% ) in breakfast for the duration of 02 months. |
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| G 2 on 60% WRB | Experimental | Participants were advised to take Watermelon rind-based bread (60% ) in breakfast for the duration of 02 month. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control on Wheat bread | Dietary Supplement | Participants were advised to take Two slices of wheat bread in breakfast for the duration of 02 months. |
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| Measure | Description | Time Frame |
|---|---|---|
| Anthropometric Measurements | for body mass index weight in kg and height in meters squared, were used to calculate changes in body size. | 60 days |
| Lipid Profile | Blood lipid profile was obtained using fasting blood samples to determine serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides were monitored pre and post intervention. | 60 days |
| Blood pressure | Blood pressure was checked using an automated sphygmomanometer. Sitting blood pressure was measured in two ways; systolic blood pressure and diastolic blood pressure after 5 minutes rest. For analysis, the average of the three readings were taken. | 60 days |
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Inclusion Criteria:
Exclusion Criteria:
Any person allergic to wheat.
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| Name | Affiliation | Role |
|---|---|---|
| Maria Aslam | University of Lahore | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Lahore | Lahore | Punjab Province | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37369281 | Result | Karimi E, Abaj F, Gholizadeh M, Asbaghi O, Amini MR, Ghaedi E, Hadi A. Watermelon consumption decreases risk factors of cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2023 Aug;202:110801. doi: 10.1016/j.diabres.2023.110801. Epub 2023 Jun 25. |
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| Experimental G1 on WRB | Dietary Supplement | Participants were advised to take 2 slices of Watermelon rind-based bread in breakfast for the duration of 02 months. |
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| Experimental G2 on WRB | Dietary Supplement | Group 2: Participants were advised to take 2 slices of Watermelon rind-based bread in breakfast for the duration of 02 months. |
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