Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study uses a natural material called Platelet-Rich Fibrin (PRF) to help improve healing after tooth removal. PRF is made from your own blood. A small amount of blood is taken from your arm and spun in a machine to make a thick, sticky layer full of platelets. These platelets help your body heal. PRF acts like a "natural bandage" and may help your gums and bone heal faster. Because it comes from your own body, it is safe and lowers the chance of infection or problems.
The goal of this research is to see if adding PRF to a bone graft (used to fill the tooth socket after extraction) can help the area heal faster and grow more new bone.
If you join this study, it will last about 4 months. You will have two teeth removed, and each socket will get a different treatment:
We will compare how well the two sides heal by looking at:
One possible risk is bruising or soreness from the blood draw. If we cannot collect enough blood (about 60-80 ml) because your veins are too small or hard to find, you will not continue in the study, and both sockets will be treated using the control method (bone graft + membrane).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRF-solidified bone graft | Experimental | Extraction socket is grafted with freeze-dried bone allograft (FDBA) mixed with autologous platelet-rich fibrin (PRF) to form a cohesive graft, without placement of a barrier membrane. |
|
| Bone Graft With Collagen Membrane | Active Comparator | Extraction socket is grafted with freeze-dried bone allograft (FDBA) and covered with a resorbable collagen membrane for ridge preservation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet-rich fibrin (PRF) | Biological | Autologous platelet concentrate prepared from the participant's blood and applied to the extraction socket, mixed with bone graft. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in alveolar ridge dimensions | Change in alveolar ridge width and height will be measured by superimposing baseline and 4-month follow-up cone-beam computed tomography (CBCT) images at standardized cross-sectional locations corresponding to the extraction sites. | 4 months after ridge preservation (prior to implant placement) |
| Measure | Description | Time Frame |
|---|---|---|
| Wound healing (re-epithelialization) | Soft tissue wound closure over extraction sites will be assessed using serial intraoral scans and analyzed to quantify changes in wound area over time. | 1, 2, 3, and 4 weeks after ridge preservation |
| Percentage of new bone formation |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Siraj Zabadi, DDS | Contact | 614-206-0298 | Zabadi.1@osu.edu | |
| Guo-Liang Cheng, DDS, MS | Contact | cheng.712@osu.edu |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This is a randomized split-mouth clinical trial in which each participant receives both interventions at different intraoral sites, allowing for a within-subject comparison
Not provided
Not provided
Not provided
| Freeze-dried bone allograft | Device | Human-derived bone graft material used to fill extraction sockets for ridge preservation |
|
| Collagen barrier membrane | Device | Resorbable membrane placed over the grafted socket to stabilize the graft and prevent soft tissue ingrowth. |
|
Bone core biopsies obtained at implant placement will be analyzed histologically to determine the percentage of newly formed bone within the grafted sites. |
| 4 months after ridge preservation (at implant placement) |
| Crestal soft tissue thickness | Soft tissue thickness at the alveolar crest will be measured clinically using a periodontal probe at the time of implant placement. | 4 months after ridge preservation (at implant placement) |
| Postoperative pain score | Participant-reported pain will be assessed using a visual analog scale (VAS, 0-100), where higher scores indicate greater pain intensity. | 1, 2, 3, and 4 weeks after ridge preservation |
| ID | Term |
|---|---|
| D014082 | Tooth Fractures |
| D050723 | Fractures, Bone |
| ID | Term |
|---|---|
| D018677 | Tooth Injuries |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D014947 | Wounds and Injuries |
Not provided
Not provided