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The study is prospective randomized clinical trial that aims to evaluate the adjunctive use of L-PRF in promoting the desired vascularization and bone fill in small and large defects following tooth extraction and report on the long-term implant and patient outcomes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group (C) | Active Comparator | Xenograft + resorbable collagen membrane |
|
| Test group (T) | Experimental | Xenograft combined with L-PRF + resorbable collagen membrane |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alveolar ridge preservation using sticky bone | Procedure | In the test group the xenograft will be mixed in with the L-PRF then placed into the socket. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Implant survival / success rate will be assessed clinically after one year of implant restoration and annually up to three years. | 2 years | |
| Patient postoperative experience will be assessed using visual analogue scale during the first week following tooth extraction and ridge preservation. | Reporting a score will be done using the pain visual analogue scale. Minimum value is 0 which is no pain and maximum value is 10 which is the worst pain ever experienced. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in width and height of alveolar ridge will be assessed at the time of tooth extraction and ridge preservation, six months (prior to implant placement) and annually up to two years using cone beam computed tomography (CBCT). | 2 years | |
| Need for additional bone augmentation will only be assessed at the time of implant placement by recording the use of bone graft (if required) in the clinical notes. |
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Inclusion Criteria:
Exclusion Criteria:
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| 2 years |
| Changes in peri-implant marginal bone level will be assessed at implant placement (baseline) and after one year of implant restoration and annually up to two years using standardized peri-apical radiograph. | 2 years |
| Soft tissue levels (midbuccal marginal tissue level changes, interproximal papilla level changes and changes in width of keratinised tissue) will be assessed at implant placement (baseline), at 1 year and at 2 years | 2 years |
| Biological complications (i.e. peri-implant diseases) will be assessed clinically using periodontal probe after one year of implant restoration and annually up to two years. | 2 years |