This study aimed to asses the effect of different remineralizing agents on the initial carious lesions at diff rant after immediately after treatment (as baseline), six months and one year.

Objectives:

Evaluation of reminralizing effect of:

1. Self- assembly peptide
2. Nano-hydroxy apitite gel
3. CPP-ACP varnish With or without laser treatment at three times intervals, immediately after treatment (as baseline), six months and one year

This study aimed to asses the effect of different remineralizing agents ( self-assembly peptide, nanohydroxy apitite gel and CPP-ACP varnish) with or without laser surface treatment on the initial carious lesions after immediately after treatment (as baseline), six months and one year using detecting device.

Inclusion Criteria: between 18 and 35 years of age, active carious (ICDAS), had received conventional manual periodontal therapy, had no systemic diseases or concomitant medication affecting salivary flow.

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Exclusion Criteria:Participant in another trial, non-carious lesion (enamel hypoplasia and dental fluorosis), Presence of abnormal oral, medical, or mental condition. Participants who had evidence of reduced salivary flow or significant tooth wear, also who had allergy to MI paste.

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