Self-assembling peptide (P11-4) exhibited an outstanding ability for biomimetic re-mineralization of incipient enamel carious lesions. It creates a 3D matrix within the subsurface of carious lesions, allowing de novo formation of Hydroxyapatite crystals, thus enabling guided enamel regeneration of the demineralized enamel structure. Addition of fluoride to P11-4 may have a synergistic effect on the remineralization potential.

This study is a randomized clinical trial, with parallel study design, 1:1 allocation ratio and superiority framework. The aim of the current trial is to evaluate remineralization potential of P11-4 combined with fluoride compared to fluoride varnish in management of incipient white spot carious lesions. Progress of the lesions will be assessed using laser fluorescence (DIAGNOdent).

Inclusion Criteria:

• Active carious white spot lesions.
• Patient compliance.
• Controlled oral hygiene condition.

Exclusion Criteria:

• Participant in another trial.
• Non carious lesions.
• Systemic diseases or concomitant medication affecting salivary flow.
• Cavitation of carious lesions.
• Parafunctional habits.
• Pregnancy.