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This study will be performed in two parts, in vivo and in vitro to assess the effect of the remineralization potential of self-assembling peptide P11-4 containing Fluoride on caries-affected dentin compared to untreated caries-affected dentin and the influence of Er, Cr: YSGG Laser treatment.
The present study will be performed to evaluate the remineralization potential of the self-assembling peptide P11-4 combined with fluoride treatment applied over demineralized dentin in occlusal carious molars.
Research objectives: To assess the effect of the two treatment modalities to enhance remineralization of demineralized dentin and clinical performance of restorations.
Research question: Will pretreatment of caries affected dentin using self-assembling peptide P11-4 containing fluoride compared to untreated caries-affected dentin will enhance the remineralization and clinical performance of composite restorations In Vitro Study
1- The present study will be performed to evaluate the remineralization potential of the self-assembling peptide P11-4 combined with fluoride and its effect on bond strength and analyze morphological changes over demineralized dentin in occlusal carious molars using Scanning Electron Microscopy (SEM).
Research Objectives: To evaluate the effect of Curodont Repair Fluoride Plus and Er,Cr:YSGG laser pretreatment on the bond strength of composite resin to superficial and deep dentin.
Research question: Will pretreatment of caries affected dentin using self-assembling peptide P11-4 containing fluoride compared to untreated caries-affected dentin will enhance bond strength?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Curodont Repair Fluoride Plus (P11-4 + fluoride) | Experimental | • In the Intervention group the Curodont Repair (P11-4 + fluoride) will be applied according to the manufacturer's instructions: The paste is gently applied to the dentin surface and left undisturbed for 5 minutes to allow self-assembly and infiltration and excess material will be removed with a gentle air spray |
|
| Beautifil II LS | Placebo Comparator | No pretreatment; proceed directly to bonding. Then the surface will dry with absorbent paper. A layer of the adhesive system (BeautiBond extrem, Shofu Inc., Kyoto, Japan) will be actively applied for 20 seconds using a micro brush. Then, the adhesive will light-cure for 10 seconds with Radii-cal LED light curing device (1200 mW/cm2) (SDI, Bayswater, Australia) (2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Curodont Repair Fluoride Plus (Self-assembling peptide remineralization agent)P11-4 peptide, fluoride, mild acidic buffer (pH ~4.5) , Credentis AG, Switzerland | Drug | Pretreatment with Curodont Repair Fluoride Plus (P11-4 + fluoride) |
| Measure | Description | Time Frame |
|---|---|---|
| Marginal integrity of restorations | Assessed using mirror and probe according to Modified USPHS Criteria | 6 months and 12 months |
| Clinical longevity of restorations | Assessed by restoration retention using mirror and probe | 6 and 12 months |
| Overall clinical performance of restorations | Evaluated using Modified USPHS Criteria | 6 and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative hypersensitivity | Evaluated using cold spray test | 6 and 12 months |
| Marginal discoloration | Assessed using digital photographic method |
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Inclusion Criteria:
o Patients aged (20 - 40) years.
Exclusion Criteria:
o Patients with systemic conditions affecting oral health or healing.
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| Beautifil II LS | Drug | Application of Giomer restorative material following standard adhesive procedures without pretreatment. |
|
|
| 6 and 12 months |
| Recurrent caries | Detected using digital photographic method | 6 and 12 months |
| Surface roughness | Evaluated using digital photographic method | 6 and 12 months |
| Surface luster | Assessed using digital photographic method | 6 and 12 months |
| ID | Term |
|---|---|
| D005459 | Fluorides |
| D017438 | Bisphenol A-Glycidyl Methacrylate |
| C020946 | triethylene glycol dimethacrylate |
| ID | Term |
|---|---|
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D007287 | Inorganic Chemicals |
| D006858 | Hydrofluoric Acid |
| D017611 | Fluorine Compounds |
| D008689 | Methacrylates |
| D000179 | Acrylates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D000098826 | Bisphenol A Compounds |
| D000098704 | Bisphenols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D003188 | Composite Resins |
| D012117 | Resins, Synthetic |
| D010969 | Plastics |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D003764 | Dental Materials |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
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