This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction.

After tooth extraction, dimensional changes occur in both hard and soft tissues, which may negatively affect future implant or prosthetic treatments. This study investigates whether the application of Titanium Platelet-Rich Fibrin (T-PRF), combined with injectable Platelet-Rich Fibrin (i-PRF), can improve healing and reduce tissue changes.

In this study, tooth extraction will be performed under local anesthesia using minimally invasive techniques. Autologous blood will be collected from the patient and processed by centrifugation to obtain T-PRF and i-PRF. The prepared materials will be applied to the extraction socket and stabilized with sutures. Healing will be monitored through clinical examinations, radiographic imaging, and ultrasonographic evaluations over a 6-month follow-up period.

Possible risks include pain, bleeding, infection, and temporary discomfort, all of which are manageable with standard clinical care.

The study is expected to contribute to the development of biologically based, minimally invasive treatment approaches that enhance tissue healing and support future dental treatments.

Inclusion Criteria:

• Systemically healthy individuals with no medical conditions that could interfere with periodontal treatment, tooth extraction, or wound healing
• Absence of systemic diseases affecting blood coagulation and no use of anticoagulant medications
• No history of blood-borne infectious diseases
• Non-smokers
• Age ≥18 years
• Patients requiring extraction of a single-rooted tooth in the maxilla or mandible
• Availability of a pre-existing CBCT scan of the planned extraction site
• Extraction site suitable for implant placement

Exclusion Criteria:

• Presence of systemic diseases that may affect periodontal treatment, tooth extraction, wound healing, or increase the risk of complications
• Presence of bleeding or coagulation disorders, or use of anticoagulant therapy
• Presence of blood-borne infectious diseases
• Smoking habit
• Age <18 years
• Psychological or mental conditions that may affect compliance with treatment or study participation
• Extraction sites not suitable for implant placement
• History of previous surgical intervention or compromised healing in the extraction site
• Pregnancy