Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy

Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy: a Randomized Controlled Clinical Study

It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.

The study cohort was randomly divided into two groups. One group received remote ischemic preconditioning one day before partial nephrectomy, while the other group underwent partial nephrectomy directly. The degree of acute renal injury on the operated side was compared between the two groups

Inclusion Criteria:

• Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery

• Aged 18 to 80

• Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)

  1. Blood routine test: WBC≥3.5×10^9/L, absolute neutrophil count ≥1.5×10^9/L, PLT≥75.0×10^9/L, HGB≥80g/L;
  2. Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;

Exclusion Criteria:

• The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery
• Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes
• Estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m²
• Horseshoe kidney
• Solitary kidney
• Pregnant women