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To conduct a multi-center, randomized, controlled clinical study aimed at formally evaluating the impact of pressing therapy on the success rate in patients with recurrent implantation failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo group | Placebo Comparator | nonpenetrating placebo needles |
|
| acupuncture group | Experimental | indwelling intradermal needles |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo Group | Device | nonpenetrating placebo needles |
| |
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy | defined as ultrasonographic detection of an intrauterine gestational sac following embryo transfer | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| β-hCG-positive pregnancy | defined as serum β-hCG concentration >10 mIU/mL on day 14 post-transfer | 1 year |
| Endometrial thickness | Endometrial thickness on Transformation Day |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan | Hubei | 430030 | China |
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| Acupuncture group |
| Device |
indwelling intradermal needles |
|
| 1 year |
| endometrial blood flow | 1 year |
| anxiety assessment | 1 year |
| depression assessment | 1 year |
| sleep quality assessment | 1 year |