Effect of Fire-Needle Combined With Regular Acupuncture on Pregnancy Outcome in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization

Effect of Fire-Needle Combined With Regular Acupuncture on Pregnancy Outcome in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization

This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture.

A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture).

Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.

Inclusion Criteria:

• (1)18 ≤age ≤40 years; (2) ≥2 previous failures of high-quality embryo transfer without clinical pregnancy

Exclusion Criteria:

• (1) preimplantation genetic testing cycles; (2) use of donor oocytes; (3) missing key data on treatment or outcome