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| ID | Type | Description | Link |
|---|---|---|---|
| 81874388 and 82274308 | Other Grant/Funding Number | National Natural Science Foundation of China |
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This study aims to evaluate whether fire-needle combined with regular acupuncture improves pregnancy outcomes in patients with recurrent implantation failure (RIF), compared to no or regular acupuncture.
A retrospective cohort study was conducted at a university-affiliated hospital. One hundred RIF patients undergoing embryo transfer between July 2024 and June 2025 were assigned to three groups: a non-acupuncture group, a regular acupuncture group, and a fire needle combination group (receiving both fire needle and regular acupuncture).
Key outcome measures, including the β-hCG positive rate, clinical pregnancy rate (CPR), and miscarriage rate (MR), were compared among the three groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| non-acupuncture group | Other |
| |
| regular acupuncture group | Experimental |
| |
| fire needle combination group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no acupuncture | Other | no acupuncture |
| |
| regular acupuncture |
| Measure | Description | Time Frame |
|---|---|---|
| β-hCG-positive pregnancy | Test for hCG in the blood day 14 post-transfer | 1 year |
| Clinical pregnancy | ultrasonographic detection of an intrauterine gestational sac following embryo transfer | 1 year |
| Miscarriage | defined as spontaneous pregnancy loss occurring after ultrasound-confirmed clinical pregnancy | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan | Hubei | 430030 | China |
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| Device |
Regular acupuncture |
|
| Fire needle combination group | Device | fire needle combination group (receiving both fire needle and regular acupuncture) |
|