Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser

Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With Polydeoxyribonucleotide (PDRN) Versus Fractional CO₂ Laser: A Randomized Controlled Clinical Study

Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.

Inclusion Criteria:

• Age Limitations: Participants must be between 18 and 50 years of age.
• Recently cut wounds or surgical scars from about (1-6 months).
• Consent to Participate: Willingness to provide informed consent and engage in all aspects of the study.

Exclusion Criteria:

• Pregnancy or breastfeeding at the time of study.

• Known allergy to PDRN.

• Medication use that could affect wound healing or inflammation, such as:

  • Isotretinoin.
  • Anticancer drugs.
  • High-dose corticosteroids.
  • Anticoagulants.

• Uncontrolled medical diseases (e.g., unstable diabetes, cardiac conditions).