Comparison of Co2 Laser Versus Co2 Laser With PRP in Scars

Comparative Study on the Efficacy of Fractional CO2 and Fractional CO2 Laser With Autologous Platelet Rich Plasma in Scars

Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars.

Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023.

Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is <25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is >75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value <0.05 as significant, was used.

Inclusion Criteria:

• Patients aged 18-50 years
• Fitzpatrick skin type III-V
• Presented with post-acne, post traumatic or post burn scars
• all those patients emotionally balanced with realistic expectations were included in the study.

Exclusion Criteria:

• scar that was less than 6 months old
• if they had an active infection or inflammatory skin condition
• having a history of malignancy
• a known connective tissue illness
• history of excessive bleeding or keloids
• unrealistic expectations
• pregnant or breastfeeding.