Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars.

Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023.

Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is <25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is >75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value <0.05 as significant, was used.

Inclusion Criteria:

• Patients aged 18-50 years
• Fitzpatrick skin type III-V
• Presented with post-acne, post traumatic or post burn scars
• all those patients emotionally balanced with realistic expectations were included in the study.

Exclusion Criteria:

• scar that was less than 6 months old
• if they had an active infection or inflammatory skin condition
• having a history of malignancy
• a known connective tissue illness
• history of excessive bleeding or keloids
• unrealistic expectations
• pregnant or breastfeeding.