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Role of Magnesium in Depressive Disorder
Because of the significant role that magnesium serves in mood regulation, the goal of this study is to evaluate the impact of starting the therapy of major depressive disorder with a combination of SSRI and Mg, as well as SSRI alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interventional Arm | Experimental | Patients in this group will be treated with SSRI and magnesium therapy for four weeks |
|
| Placebo | Placebo Comparator | Patients in this group will be treated with SSRI as a placebo in interventional treatment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Use of magnesium with SSRI | Drug | Impact of combination of SSRI and Magnesium in Major Depressive Disorder |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in severity of depressive symptoms | Change in severity of depressive symptoms, measured by the difference in mean scores on the Beck Depression Inventory-II (BDI-II) from baseline to 4 weeks post-intervention | Four Weeks |
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Inclusion Criteria:
All patients of above 18 years diagnosed with DSM who had MDD and receiving SSRI alone and SSRI plus magnesium.
Exclusion Criteria:
Individuals who recently underwent treatment with electroconvulsive therapy, have a history of epilepsy or other severe neurological problems, have experienced a head injury, are cognitively impaired, and have comorbid conditions such as liver, renal, cardiovascular, neurological, or endocrine, or respiratory problems, or are pregnant or nursing mothers
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| Name | Affiliation | Role |
|---|---|---|
| Atif Najum, MBBS, FCPS | CMH Multan | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Combined Military Hospital (CMH) | Multan | Punjab Province | 60000 | Pakistan |
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| Label | URL |
|---|---|
| Older adults with hypertension have an increased risk of depression compared to their younger counterparts | View source |
| Management of treatment-resistant depression: challenges and strategies. Neuropsychiatric disease and treatment. | View source |
| Dietary magnesium intake and risk of depression. Journal of affective disorders. |
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Patient Confidentiality
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| ID | Term |
|---|---|
| D017367 | Selective Serotonin Reuptake Inhibitors |
| ID | Term |
|---|---|
| D014179 | Neurotransmitter Uptake Inhibitors |
| D049990 | Membrane Transport Modulators |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
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| SSRI | Drug | Only SSRI will be given |
|
| View source |
| Possible relation between consumption of different food groups and depression. | View source |
| The way to a human's brain goes through their stomach: dietary factors in major depressive disorder | View source |
| D020164 | Chemical Actions and Uses |
| D018377 | Neurotransmitter Agents |
| D018490 | Serotonin Agents |
| D045505 | Physiological Effects of Drugs |