Combination Therapy of Different Antidepressants With Dietary Supplements

Comparative Efficacy of Antidepressants With L-methylfolate, B12, and Magnesium in Depressive Disorders

The aim of this clinical trial is to compare the effect of antidepressants in combination with different dietary supplements in patients with depression. Our main objective is to compare the efficacy of antidepressants in combination with either L-methyl folate, Vit B12, or magnesium) in patients with depressive disorders. The levels of depressive symptoms as measured by the Patient Health Questionnaire (PHQ-9) at base level and during follow-up.

This is an open-label study assessing the comparative efficacy of antidepressants in combination therapy of either L-methylfolate, mecobalamin, or magnesium in patients with Depressive Disorder. The plan is to enroll 84 patients with depression based on Patient Health Questionnaire (PHQ-9) score of 9 and above, which is a valid and reliable Structured Clinical Interview. The investigators will collect data from the enrolled patient populations. The participants will be able to receive their results, on request, upon completion of the study. The investigators hypothesize that depressive symptoms can be improved by the addition of above mentioned nutritional supplementations with antidepressant medication.

Inclusion Criteria:

• Patients with Depressive Disorder having PHQ-9 Score 9 and above
• Age 12 and above
• Patients having low/marginal and low normal levels for arms 2 and 3 of respective supplements
• Patients having low/normal serum magnesium for arm 4

Exclusion Criteria:

• Patients having psychiatric diagnosis other than Depressive Disorder according to the International Classification of Diseases 11th Revision (ICD-11)
• History of kidney disease, myasthenia gravis
• Mentally handicapped or terminally ill patients
• Age less than 12 years
• Patients already taking multiple nutritional supplements
• Patients on polypharmacy with potential interactions with antidepressants and supplements in this study.