Role of Magnesium Supplementation in the Treatment of Depression
Role of Magnesium Supplementation in the Treatment of Depression
The objective of this project is to test the hypothesis that magnesium supplementation will decrease depressive symptoms in adults.
This study takes place over 12 consecutive weeks. While the investigators will follow the volunteers for the full 12 weeks volunteers will only take magnesium supplements for 6 consecutive weeks. Volunteers will be randomly assigned to start the supplement at week 1 or week 7. Volunteers will take two supplement two times a day for a total of 248 mg elemental magnesium daily in the form of magnesium chloride. This amount of magnesium is less than the tolerable upper limit of 350 mg per day. The supplements will be provided. Volunteers will be asked to maintain their normal diet for the 12 weeks of the study.
The primary outcome measure is the PHQ-9 questionnaire, a validated measure of depression. Secondary measures include the GAD-7 for Anxiety and side effects.
Inclusion Criteria:
Exclusion Criteria:
Active delirium or dementia
Medicinal treatment for bipolar disorder, personality disorder or schizophrenia,
Glomerular Filtration Rate of less than 60
Irritable Bowel Disease
Inflammatory Bowel Disease
GERD
Gastritis
Pregnant as reported by potential volunteer
Myasthenia Gravis
Planned elective surgery
Currently taking
Unable or unwilling to stop taking a magnesium supplement