Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Pavia | OTHER |
Not provided
Not provided
Not provided
Not provided
The aim of the study is to analyse the resected portion of aneurysmatic ascending aorta in order to assess its strength to rupture, standardise the various measurements performed within the lab and try to correlate these qualitative results with quantitative results (regarding aortic diameter, valve morphology and aortic wall thickness).
The aortic wall is subjected to mechanical stresses in radial, circumferential, and longitudinal directions. The amount of these shear stresses varies with the distribution of velocity across the vessel lumen and with local vessel geometry.
Diseases affecting the thoracic aorta can be categorized into acute and chronic. Chronic aortic pathologies are chronic aortic dissections and aortic aneurysms.
Today, there are computational tools available to permit the calculation of stresses of the aortic wall.
For the above-mentioned reasons, this study becomes of extreme interest as it may be capable of further assessing the mechanical properties of the dilated aortic tissue, its' strength to rupture and stiffness, in order to provide an overview of the fragility of ascending aortic aneurysms. This parameter, associated to the diameter of the pathological aorta, may provide an additional tool regarding the clinical history of patients and insight concerning surgical indication.
Matter of factly, knowing the risk of rupture based on diameter may have strong implications on the preoperative evaluation of patients and the decision-making process.
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Strength to rupture | Define the strength to rupture of the removed aortic segments and its relation with the circumferential and longitudinal direction along the aortic axis. | During laboratory testing |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate aortic characteristics | Evaluate multiple characteristics of the surgically excised pathologically enlarged aortic segments: shape alteration, tensile strength, elasticity capacity. | From surgery to laboratory testing |
| Measure | Description | Time Frame |
|---|---|---|
| Standardize mechanical measurements | Assess from a methodological point of view the various aspects and results of the different test and identify the ideal testing method (uniaxial vs biaxial) | During laboratory testing |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients undergoing cardiac surgery for ascending or aortic root aneurysms.
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Policlinico San Donato | Recruiting | San Donato Milanese | MI | 20097 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26356765 | Result | Ferrara A, Morganti S, Totaro P, Mazzola A, Auricchio F. Human dilated ascending aorta: Mechanical characterization via uniaxial tensile tests. J Mech Behav Biomed Mater. 2016 Jan;53:257-271. doi: 10.1016/j.jmbbm.2015.08.021. Epub 2015 Aug 20. | |
| 21616506 | Result | Khanafer K, Duprey A, Zainal M, Schlicht M, Williams D, Berguer R. Determination of the elastic modulus of ascending thoracic aortic aneurysm at different ranges of pressure using uniaxial tensile testing. J Thorac Cardiovasc Surg. 2011 Sep;142(3):682-6. doi: 10.1016/j.jtcvs.2010.09.068. Epub 2011 May 25. |
Not provided
Not provided
the investigators not planning to share IPD, because anonymised data might be used for future scientific publications
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001014 | Aortic Aneurysm |
| D000094628 | Aortic Root Aneurysm |
| D000082882 | Bicuspid Aortic Valve Disease |
| D001019 | Aortic Rupture |
| ID | Term |
|---|---|
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001018 | Aortic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Resected aneurysmal aortic segment
| 12683565 | Result | Vorp DA, Schiro BJ, Ehrlich MP, Juvonen TS, Ergin MA, Griffith BP. Effect of aneurysm on the tensile strength and biomechanical behavior of the ascending thoracic aorta. Ann Thorac Surg. 2003 Apr;75(4):1210-4. doi: 10.1016/s0003-4975(02)04711-2. |
| 34496896 | Result | Surman TL, Abrahams JM, Manavis J, Finnie J, O'Rourke D, Reynolds KJ, Edwards J, Worthington MG, Beltrame J. Histological regional analysis of the aortic root and thoracic ascending aorta: a complete analysis of aneurysms from root to arch. J Cardiothorac Surg. 2021 Sep 8;16(1):255. doi: 10.1186/s13019-021-01641-5. |
| 35134955 | Result | Dong H, Liu M, Qin T, Liang L, Ziganshin B, Ellauzi H, Zafar M, Jang S, Elefteriades J, Sun W. Engineering analysis of aortic wall stress and root dilatation in the V-shape surgery for treatment of ascending aortic aneurysms. Interact Cardiovasc Thorac Surg. 2022 Jun 1;34(6):1124-1131. doi: 10.1093/icvts/ivac004. |
| 29262774 | Result | Plonek T, Zak M, Burzynska K, Rylski B, Gozdzik A, Kustrzycki W, Beyersdorf F, Jasinski M, Filipiak J. The combined impact of mechanical factors on the wall stress of the human ascending aorta - a finite elements study. BMC Cardiovasc Disord. 2017 Dec 20;17(1):297. doi: 10.1186/s12872-017-0733-9. |
| D017545 |
| Aortic Aneurysm, Thoracic |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D006331 | Heart Diseases |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D017542 | Aneurysm, Ruptured |
| D012421 | Rupture |
| D014947 | Wounds and Injuries |