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The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.
Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Patients scheduled for elective conventional aneurysm repair | ||
| 2 | Patients scheduled for emergent conventional aneurysm repair | ||
| 3 | Patients scheduled for aortic bypass surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Aneurysm wall strength | Post-operative |
| Measure | Description | Time Frame |
|---|---|---|
| Extra Cellular Matrix components (Glucoaminoglycans) | post-operative | |
| Biochemical blood analysis | post-operative | |
| MMP content |
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Inclusion Criteria:
Exclusion Criteria:
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Tertiary care clinic. Patients scheduled for transbadominal aortic surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maarten Truijers, MD | Contact | 0031-24-3615333 | M.Truijers@chir.umcn.nl |
| Name | Affiliation | Role |
|---|---|---|
| Jan Blankensteijn | Radboud University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alysis Zorggroep, Rijnstate Hospital | Recruiting | Arnhem | Gelderland | 6815AD | Netherlands |
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| ID | Term |
|---|---|
| D017544 | Aortic Aneurysm, Abdominal |
| D000783 | Aneurysm |
| D012421 | Rupture |
| ID | Term |
|---|---|
| D001014 | Aortic Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001018 | Aortic Diseases |
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whole blood, serum, white cells, urine, tissue
| post-operative |
| Degree of inflammation | Post-operative |
| Radboud University Nijmegen Medical Center | Recruiting | Nijmegen | Gelderland | 6525GA | Netherlands |
|
| D014947 |
| Wounds and Injuries |