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The goal of this study is to learn about the effects of eating kimchi on the gut health of healthy adults in the USA. The investigators will be researching the changes in the gut microbiome, biomarkers of gut health and cardiometabolic health after consuming fermented and unfermented cabbage.
The main questions it aims to answer are:
Does eating kimchi (fermented cabbage) result in enrichment of lactic acid bacteria in the stools of participants? Does eating kimchi result in metabolic changes in the gut microbiome, biomarkers of gut and cardiometabolic health of participants? Researchers will compare a group of participants eating fermented cabbage (kimchi) daily to a group of participants eating non-fermented cabbage daily.
Participants will:
Eat kimchi or cabbage daily for 3 weeks. Visit the study site for brief visits up to 5 times. Have blood drawn and provide a fecal sample 2 times - at beginning and end of the 3 week study.
Keep occasional records of food intake and questionnaires about any gastrointestinal symptoms that participants may have.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kimchi | Experimental |
| |
| Cabbage | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 60 grams per day of intervention food | Other | Non-fermented cabbage |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in fecal Lactic Acid Bacteria (LAB) | Baseline and week 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal Metabolites - Change in short chain fatty acids (SCFA) and secondary bile acids (BA) | Baseline and 3 weeks | |
| Gut integrity and health - Change in fecal calprotectin, fecal lipocalin, and fecal sIGA | Baseline and 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index (BMI) | To derive the Body Mass Index (BMI) the following will be done: Height will be measured in meters. Weight will be measured in kilograms. These values will be aggregated to arrive at one reported value to report BMI in kg/m2 | Baseline and 3 weeks |
| Dietary Records and nutritional analysis of Macronutrients |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ragle Human Nutrition Center | Recruiting | Davis | California | 95616 | United States |
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| 60 grams per day of intervention food |
| Other |
Kimchi fermented cabbage |
|
| Gut integrity and health - Change in plasma lipopolysaccharide binding protein (LBP), lipopolysaccharide (LPS), zonulin, and sCD14 | Baseline and 3 weeks |
| Immune biomarkers - Change in plasma IL-6, TNF-alpha, hsCRP | Baseline and 3 weeks |
| Cardiometabolic biomarkers - Change in lipid panel (TC, LDL, HDL, TG), and oxidized LDL (oxLDL) | Baseline and 3 weeks |
| Qualitative self-assessment of gut associated health - Change in Gastrointestinal Symptom Rating Scale (GSRS) | This questionnaire rates gastrointestinal symptoms over the past 7 days. A higher score indicates presence and increasing severity of symptoms and level of discomfort. | Baseline and 3 weeks |
| Qualitative self-assessment of gut associated health - Change in Digestion-associated Quality of Life Questionnaire (DQLQ) | This questionnaire measures the effect of digestive symptoms on daily life over the past 7 days. A higher score indicates a lower (worse) digestion-associated Quality of Life. | Baseline and 3 weeks |
ASA24 (Automated Self Assessment of diet on the NIH website) will be used to record 24 hours of diet intake. Macronutrients will be measured in grams/day. |
| Baseline, week 1 of intervention, week 3 of intervention |
| Dietary records and assessment of Fiber intake | ASA24 (Automated Self Assessment of diet on the NIH website) will be used to record 24 hours of diet intake. Dietary fiber will be measured in grams/day. | Baseline, weeks 1 and 3 |
| Waist Circumference | Waist circumference will be measured in centimeters | Baseline and 3 weeks |
| Blood Pressure | Blood pressure will be measured by automated upper arm cuff to read systolic and diastolic pressure in units of mm Hg. Normal pressure is considered 120/80 mm Hg. | Baseline and 3 weeks |
| UC Davis Ragle Human Nutrition Research Center | Recruiting | Davis | California | 95616 | United States |
|