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| Name | Class |
|---|---|
| California Walnut Commission | OTHER |
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This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Snack Type 1: Walnuts | Experimental | Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks). |
|
| Snack Type 2: Pretzels | Active Comparator | Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Snack Type 1: Walnuts | Other | Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team. |
| Measure | Description | Time Frame |
|---|---|---|
| Percent change in Blood Oxygen Level Dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging | Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, amygdala, and prefrontal cortex. | Baseline, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in percent body fat | Change in percent body fat from baseline to after the 12-week intervention. | Baseline, 12 weeks |
| Change in appetite response to a meal | Change in appetite response to a meal (area under the curve for visual analog scale [VAS] ratings of hunger and satiety across fasted and fed states) from baseline to after the 12-week intervention. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Allison Hild, BS | Contact | 3037249024 | allison.hild@cuanschutz.edu | |
| Kristina T Legget, PhD | Contact | 303-724-5809 | kristina.legget@cuanschutz.edu |
| Name | Affiliation | Role |
|---|---|---|
| Kristina T Legget, PhD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Recruiting | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D015431 | Weight Loss |
| D001835 | Body Weight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D012816 | Signs and Symptoms |
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| Snack Type 2: Pretzels | Other | Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team. |
|
| Baseline, 12 weeks |
| Change in food cravings | Change in food cravings (using the Food Cravings Questionnaire) from baseline to after the 12-week intervention | Baseline, 12 weeks |
| Change in dietary restraint | Change in dietary restraint (measured using the dietary restraint subscale of the Three Factor Eating Questionnaire) from baseline to after the 12-week intervention. | Baseline, 12 weeks |
| Change in reward-based eating drive | Change in reward based eating drive (measured using the Reward-Based Eating Drive-13 questionnaire) from baseline to after the 12-week intervention. | Baseline, 12 weeks |
| Change in waist circumference | Change in waist circumference (cm) from baseline to after the 12-week intervention | Baseline, 12 weeks |
| Change in body weight | Change in body weight (kg) from baseline to after the 12-week intervention | Baseline, 12 weeks |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |