Comparison Between Two Drugs in Sedation of Upper GI Endoscopy

Ketamine - Dexmedetomidine(Ketodex) Versus Propofol -Midazolam for Sedation in Patients Undergoing Upper Gastrointestinal Endoscopy

The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

Secondary outcome :

• Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
• Hemodynamics (MAP,HR) & oxygen saturation
• Drug side effects (nausea,vomitting,agitation)
• Endoscopist satisfaction

Inclusion Criteria

• Patient acceptance
• Adults aged 21-60 years.
• Both sexes
• BMI<35 kg/m2
• ASA physical status :I& II
• Patients Undergoing Gastrointestinal endoscopy
• Duration <30mintues

Exclusion Criteria:

• • Known allergy to any of the study drugs

  • Unstable Cardiovascular disease
  • Moderate to severe respiratory diseases