This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy. We compare between 2 combinations as regard hemodynamic stability, post operative side effects as occurrence of delirium, nausea, vomiting, headache, hallucination or agitation.

Inclusion Criteria:

• American Society of Anesthesiologists physical status I to II.
• Age between 18 and 60 years.
• Both sexes.

Exclusion Criteria:

• Having severe heart, lung, liver disease, kidney failure, or bleeding disorder.
• Patients having fever, hypothermia or infection, electrolyte disorders, such as hypokalemia and hypocalcaemia, acid-base disorder, allergy to drugs to be used.