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This is a single-center, non-interventional, observational, cross-sectional clinical study designed to quantitatively and qualitatively characterize skin properties in a cohort of 100 Chinese female Subjects aged 20 to 70 years. The study involves no product application and poses minimal risk to participants. The primary objectives are to establish a comprehensive skin aging profile database, characterize skin color, aging signs, and biomechanical properties, and create a histomorphometric database for the development and validation of ordinal photographic scales for aging research. Data will be collected through questionnaires, clinical assessments (including LC-OCT imaging), standardized photography, and non-invasive biophysical measurements. All procedures will be conducted in accordance with the ethical principles originating from the Declaration of Helsinki, the International Council for Harmonisation Good Clinical Practice (ICH-GCP) guidelines, and the relevant laws and regulations of China (including the *Measures for the Ethical Review of Biomedical Research Involving Human Subjects*). All data will be anonymized and stored securely.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 20 to 29 Years old | |||
| Group 30 to 39 Years old | |||
| Group 40 to 49 Years old | |||
| Group 50 to 59 Years old | |||
| Group 60 to 69 Years old |
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| Measure | Description | Time Frame |
|---|---|---|
| Epidermal Thickness | Single visit, day 1 | |
| Dermal-Epidermal Junction (DEJ) Undulation Index | Single visit, day 1 | |
| Mean Dermal Reflectivity | Single visit, day 1 | |
| Stratum Corneum Thickness | Single visit, day 1 | |
| Correlation between LC-OCT parameters and chronological age | Single visit, day 1 | |
| Skin colorimetric parameter L*a*b* | Single visit, day 1 | |
| Correlation between LC-OCT parameters and clinician-graded scores | Single visit, day 1 | |
| Correlation between LC-OCT parameters and questionnaire factors | Single visit, day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinician-graded score of skin texture/pores | Single visit, day 1 | |
| Clinician-graded score of skin pigmentation | Single visit, day 1 | |
| Clinician-graded score of facial wrinkles |
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Inclusion Criteria:
Exclusion Criteria:
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Approximately 100 healthy Chinese female Subjects, evenly distributed across age groups (20-29, 30-39, 40-49, 50-59, 60-70 years).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yanwen Jiang | Contact | 13501700841 | jiangyanwen@china-norm.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HKRI Centre One | Recruiting | Shanghai | Shanghai Municipality | 200072 | China |
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| Single visit, day 1 |