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| Name | Class |
|---|---|
| Centre de Pharmacologie Clinique Applique a la Dermatologie | OTHER |
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This is a single-center, single visit study conducted in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen measured non-invasively (LC-OCT). No product will be tested during the study.
Single-center, single visit study in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen measured non-invasively (LC-OCT). No product will be tested during the study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1: 20-30 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
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| Group 2: 31-40 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
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| Group 3: 41-50 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
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| Group 4: 51-60 years |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LC-OCT acquisitions on the forehead | Diagnostic Test | During the study visit, the investigator will for each subjects in Group 1: - Perform standardized photographs using the ColorFace Group 2: - Perform standardized photographs using the ColorFace Group 3: - Perform standardized photographs using the ColorFace Group 4:
Group 5:
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| Measure | Description | Time Frame |
|---|---|---|
| Non-invasive tissue imaging: 3D imaging through Line-field Confocal Optical Coherence Tomography technology (LC-OCT) acquisitions | Line-field Confocal Optical Coherence Tomography technology (LC-OCT) provides a unique 3D imaging modality, allowing the user to switch from a histology-like vertical mode to confocal-like horizontal mode and to record a 3D stack of tissue volumes in situ. With this technique skin can be imaged in vivo in its native state without further preparation. The superficial dermis can be clearly imaged using a live vertical, live horizontal and 3D mode. This assessment will be performed on the face (forehead) with the LC-OCT deepLive™ (DAMAE). This non invasive image will helps to characterize and quantify new metrics of skin aging linked to the dermal fibers network (collagen and elastin) such as caracterisation of the density and length of dermis fibers during aging. | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Standardized photographs of the face (front and 45° left and right sides) | Standardized photographs of the face (front and 45° left and right sides) will be performed using the ColorFace (Newtone Technologies, Lyon, France). The ColorFace® has multiple lighting modes and can acquire up to 5 images in one setting from a user-definable shooting template without technician intervention. Subjects will be photographed using the following modalities:
They serve for illustration purposes of visible signs during skin aging . |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy female volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Catherine QUEILLE-ROUSSEL, MD | CPCAD, Hôpital l'Archet 2 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CPCAD, Hôpital l'Archet 2 | Nice | 06000 | France |
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The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
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| Group 5: 61-75 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
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| Perform standardized photographs using ColorFace | Device | Photographs |
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| LC-OCT acquisitions on forehead | Device | Image acquisition |
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| Perform photo-shooting using smartphones | Device | photo from back and front camera pictures and selfie |
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| Day 1 |
| Photo shooting | Photo shooting (Back and Front camera pictures) will be performed using an iPhone 15. Back camera pictures will be taken by a trained personnel and the front camera picture will be taken by the subject himself after a brief training by the study personnel. These photos will serve for grading facial aging: Comparing the clinical assessments made by three dermatologists with those obtained by an AI-based scoring system that analyses selfie pictures. | Day 1 |
| Questionnaire | Subjects will be asked to complete a self-assessment questionnaire about their lifestyle habits in order to assess the link between lifestyle habits and aging. | Day 1 |