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Hemodymanic stress response to direct laryngoscopy and endotracheal intubation is a known phenomenon that occur in almost every patient undergoing general anesthesia before surgical procedure. This response leads to sudden rise in heart rate and blood pressure which may cause serious complications in compromised patients having cardiovascular diseases. There are certain drugs which are used to blunt this response and to prevent the life threatening complications. Intravenous Lignocain is commonly used drug to blunt the laryngoscopic response in our setup. Intravenous Dexmedetomidine is a newer and rarely used drug to prevent stress response to direct laryngoscopy and endotracheal intubation. This study aims to compare the efficacy of both the drugs to provide better control of complications like Arrythmias, stroke and cardiovascular instability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group L | Active Comparator | Group L received IV Lignocain 1.5mg/kg before induction. |
|
| Group D | Active Comparator | Group D received IV Dexmedetomidine infusion 10mics/ kg over 10min before induction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intravenous Dexmedetomidine infusion | Drug | Dexmedetomidine infusion with dose of 10mics/kg given 10min before induction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic stress response | Rise in Heart rate and mean arterial pressure | 1 minute and 3 minute after endotracheal intubation |
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Inclusion Criteria:
Patients undergoing general anesthesia for any elective surgery Having ASA 1 or 2 Having mallapatti 1 or 2 Having BMI in between 18-30 kg/m2
Exclusion Criteria:
Lack of consent Anticipated difficult airway Pregnancy Sensitivity to either drug
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| Name | Affiliation | Role |
|---|---|---|
| Maryam Maryam | Shaheed Mohtarma Benazir Bhutto Institue of Trauma | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maryam | Karachi | Sindh | 7523 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34000325 | Background | Mahiswar AP, Dubey PK, Ranjan A. Comparison between dexmedetomidine and fentanyl bolus in attenuating the stress response to laryngoscopy and tracheal intubation: a randomized double-blind trial. Braz J Anesthesiol. 2022 Jan-Feb;72(1):103-109. doi: 10.1016/j.bjane.2021.02.060. Epub 2021 May 14. |
| Label | URL |
|---|---|
| J NTR Univ Health Sci 2015;4:86-90 | View source |
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Single blinded, randomised control trial
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| Intravenous Lignocain | Drug | Intravenous ligoncain 1.5mg/kg given 90sec before induction. |
|
| ID | Term |
|---|---|
| D013610 | Tachycardia |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
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