Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy

Direct laryngoscopy and intubation are painful stimulus that activates sympathoadrenal discharge which results in intense cardiovascular reflex i.e. tachycardia and hypertension. In this study we will compare effects of intravenous dexmedetomidine, fentanyl and lidocaine for attenuation of these reflexes in patient undergoing laproscopic cholecystectomy. how these agents will effect hemodynamic response during pneumoperitoneum. Tertiary objective will be to observe sedation, perioperative complications and recovery in these patients.

Inclusion Criteria:

• ASA-I and ll patients
• Male and female patient of age 20-70 years.
• Undergoing Elective surgery
• Intubation by skilled anesthetist of at least 2 years' experience
• Intubation not more than 45 seconds

Exclusion Criteria:

• Patients with uncontrolled DM, HTN, IHD, endocrine or autonomic dysfunction
• Pregnant and lactating females
• Short thick neck with anticipated difficult intubation
• Any sort of obstructive restrictive or reactive airway disease
• Patient allergic to any of the study medications.
• Obese patients, Narcotic addicts

Patients do not know about the interventions.