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The aim of this study to evaluate the microbial profile in gastritis and healthy patients in different periodontal conditions via next generation technologies.
This study aims to determine the density of bacteria associated with periodontal disease and to evaluate oral dysbiosis in gastritis patients using metagenomic analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gastritis | Patients diagnosed with gastritis via endoscopic method and without other systemic diseases |
| |
| Systemically healthy | Patients without any systemic disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| saliva collection | Other | collecting unstimulated saliva |
|
| Measure | Description | Time Frame |
|---|---|---|
| Salivary microbial profile | To compare the oral flora profiles of the study groups, a microbiome-based next-generation sequencing approach targeting the 16S rRNA gene was employed. In this metagenomic study, following DNA extraction, phylogenetic classification was performed using the V3-V4 hypervariable regions of the 16S rRNA gene. Using the obtained data, total bacterial diversity and density were compared through alpha and beta diversity analyses. Bacterial taxa that differed between the groups were identified using LEfSe analysis. | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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older than 18 years, have no systemic disease other than gastritis, non smoker participants
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aydın Adnan Menderes University | Aydin | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42332672 | Derived | Erdem Altinyurek E, Ozturk VO. Evaluation of periodontal status in gastritis patients with clinical and microbiological parameters. BMC Oral Health. 2026 Jun 22. doi: 10.1186/s12903-026-08835-0. Online ahead of print. |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D005756 | Gastritis |
| D064806 | Dysbiosis |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
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| D004066 |
| Digestive System Diseases |
| D013272 | Stomach Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |