Salivary Bacterial Profiles in Relation to Periodontal Treatment

Short and Long Term Alterations of Subgingival and Salivary Microbiota in Relation to Periodontal Treatment

The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Inclusion Criteria:

- Manifest chronic periodontitis according to international classification

Exclusion Criteria:

• Other treatment requiring oral conditions
• Systemic antibiotics within the latest 6 months
• Systemic diseases and medications with known associations to periodontitis
• Pregnancy and breastfeeding