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| Name | Class |
|---|---|
| The Forsyth Institute | OTHER |
| Rigshospitalet, Denmark | OTHER |
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The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to discontinuation of oral hygiene.
35 orally healthy individuals will be enrolled in this study, in which they will discontinue regular oral hygiene procedures for a period of 10 days. Clinical registrations and collection of microbiological samples (supragingival and saliva) will be performed at baseline and 4, 7 and 10 days after discontinuation of regular oral hygiene, and will be repeated 14 days after regular oral hygiene has been resumed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oral hygiene discontinuation group | Experimental | The intervention of the present study is discontinuation of regular oral hygiene procedures for a period of 10 days. Discontinuation of oral hygiene will allow undisturbed biofilm formation (supragingival dental plaque) along the gingival margin of the teeth. After 10 days all individuals will resume regular oral hygiene. Clinical registrations and collection of microbiological samples (supragingival and saliva) will be performed at baseline and 4, 7 and 10 days after discontinuation of regular oral hygiene, and will be repeated 14 days after regular oral hygiene has been resumed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral hygiene discontinuation group | Procedure | Discontinuation of regular oral hygiene for 10 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of changes in α-diversity in saliva samples before and after discontinuation of regular oral care | Comparison of α-diversity in saliva samples before and after discontinuation of regular oral hygiene | 10 days of discontinuation of regular oral care and 14 days after resuming regular oral care |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of species specific changes in saliva samples before and after discontinuation of regular oral care | Comparison of relative abundance of bacterial species in saliva samples at baseline to samples collected 10 days after discontinuation of regular oral hygiene and to samples collected 14 days after oral hygiene procedures has been resumed | 10 days of discontinuation of regular oral care and 14 days after resuming regular oral care |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Belstrøm, DDS, PhD | University of Copenhagen | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29662960 | Derived | Belstrom D, Sembler-Moller ML, Grande MA, Kirkby N, Cotton SL, Paster BJ, Twetman S, Holmstrup P. Impact of Oral Hygiene Discontinuation on Supragingival and Salivary Microbiomes. JDR Clin Trans Res. 2018 Jan;3(1):57-64. doi: 10.1177/2380084417723625. Epub 2017 Jul 31. |
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| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| ID | Term |
|---|---|
| D009057 | Stomatognathic Diseases |
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