Remimazolam Consumption: TCI vs. Manual Infusion

Comparison of Remimazolam Consumption According to Administration Method in Patients Undergoing Cerebrovascular Bypass Surgery: A Prospective Randomized Trial

The purpose of this prospective randomized controlled trial is to compare the total consumption of remimazolam between two different administration methods-Target-Controlled Infusion (TCI) and manual infusion-in patients undergoing cerebrovascular bypass surgery.

Inclusion Criteria:

• Patients scheduled to undergo cerebrovascular bypass surgery under general anesthesia.
• American Society of Anesthesiologists (ASA) Physical Status 1, 2, or 3
• Adults aged 19 years or older
• Patients who have provided prior written informed consent to participate in the study

Exclusion Criteria:

• Patients who do not consent to participate in the research
• Patients classified as ASA Physical Status 4
• Patients with a BMI ≤18.5 kg/m2 or 35.0 ≥ kg/m2
• History of allergy to benzodiazepine-class medications
• Patients with acute narrow-angle glaucoma
• Patients in a state of shock or coma
• Acute alcohol intoxication with suppressed vital signs , or patients with alcohol or drug dependency
• Presence of Sleep Apnea Syndrome or severe/acute respiratory failure
• Patients with lactose intolerance or hypersensitivity to Dextran 40