Effects of Remimazolam on the Intraoperative Hemodynamics in Bypass Surgery

Effects of Remimazolam on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial

This study is a randomized, controlled trial. A total of 72 patients will be randomized to receive remimazolam anesthesia or balanced anesthesia (propofol + desflurane) during extracranial-intracranial bypass surgery.

Inclusion Criteria:

• Patients who undergo elective extracranial-intracranial bypass surgery
• American Society of Anesthesiologists grade 1,2,3
• Age > 18 years old

Exclusion Criteria:

• Refuse to participate to the study
• American Society of Anesthesiologists grade 4
• Body Mass Index < 18.5 kg/m2 or > 35 kg/m2
• Allergic history of benzodiazepine
• Pregnant
• Acute narrow-angle glaucoma
• Shock or Coma
• Acute alcohol addicted
• Obstructive sleep apnea
• dependency on alcohol or drug
• Severe acute respiratory insufficiency
• Hypersensitivity to Dextran 40