Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients

Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in Patients Undergoing Coronary Artery Bypass Grafting

Remimazolam is a novel ultra-short-acting benzodiazepine. Several studies demonstrated that its efficacy as a sedative hypnotics for general anesthesia is non-inferior to propofol. However, evidence on the hemodynamic stability of remimazolam for the anesthesia induction in patients undergoing coronary artery bypass grafting is lacking. This prospective randomized trial aims to compare hemodynamic stability during anesthesia induction between remimazolam and propofol in patients undergoing coronary artery bypass grafting.

Inclusion Criteria:

• Adult patient (aged 19 years or older) who scheduled for elective coronary artery bypass grafting

Exclusion Criteria:

• Patients who refuse to participate
• Concomitant heart valve surgery or thoracic aorta surgery
• Emergent surgery
• Preoperative sedation
• Intubated state
• Patients with mechanical circulatory assist device
• Preoperative use of inotropes or vasopressors
• History of allergy or adverse reaction to study drugs
• Rapid sequence intubation
• Lactose intolerance
• Peanut allergy