Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane.
This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.
After tooth extraction, a progressive remodeling process occurs that is often associated with significant alveolar bone resorption, particularly in sites with compromised bony walls. Alveolar ridge preservation is a surgical procedure aimed at minimizing this physiological resorption by placing grafting materials within the extraction socket and protecting them with a barrier membrane.
In the present protocol, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.
In one study group, in addition to the surgical procedure, postoperative biostimulation using low-intensity photonic nanotechnology is applied. This adjunctive therapy is intended to enhance cellular metabolism, modulate inflammation, and accelerate both soft and hard tissue healing. The combined approach aims to preserve alveolar volume more effectively, improve the quality of regenerated tissues, and create a more favorable prosthetic environment for subsequent implant rehabilitation.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Traditional Alveolar Preservation | Active Comparator | The socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and dermal membrane |
|
| therapeutic wavelengths Alveolar Preservation | Experimental | Therapeutic wavelengths are applied as part of the alveolar preservation protocol. The extraction socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and subsequently covered with a dermal membrane to support healing and tissue regeneration. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Socket Preservation | Procedure | After atraumatic tooth extraction, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration. |
| Measure | Description | Time Frame |
|---|---|---|
| VAS | Postoperative pain assessment using the Visual Analog Scale (VAS) (1-10) | 1 day , 3 days , 7 days ,14 days |
| Analgesic consumption | recorded as the number of ibuprofen 400 mg tablets taken | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Histological Evaluation |
| 4- 6 month |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Giuseppe D'Albis, Dr. | Contact | +393495103642 | giuseppe.dalbis@uniba.it | |
| Domenico Patarino, Dr. | Contact | +393394359824 | domenico.patarino@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Giuseppe D'Albis, Dr. | University of Bari Aldo Moro | Principal Investigator |
| Domenico Patarino, Dr. | Private Practice | Principal Investigator |
| Saverio Capodiferro, Prof. Dr. |
Not provided
Not provided
| ID | Term |
|---|---|
| D014084 | Tooth Avulsion |
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D018677 | Tooth Injuries |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D014947 | Wounds and Injuries |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| University of Bari Aldo Moro |
| Study Director |
| D001847 |
| Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |