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The primary objective of this study was to compare the efficacy of using allograft, autogenous tooth graft, and beta-tricalcium phosphate for alveolar ridge preservation (ARP) by examining the alveolar ridge height and width at baseline and 3 months after the ARP both clinically and radiographically. The secondary objective was to evaluate the quality of the newly formed bone using histomorphometric analysis.
This randomized controlled clinical trial included thirty patients. ARP was performed using either Allograft (Allograft group n=10), Tooth graft (Toothgraft group n=10), and beta tri-calcium- phosphate (beta tri-calcium group n=10). Changes in alveolar ridge dimensions were evaluated clinically and radiographically using cone beam computed tomography at baseline and 3 months. Core bone biopsy samples were obtained 3 months post-extraction during implant placement for histomorphometric analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alveolar ridge preservationwith tooth graft | Active Comparator | tooth graft |
|
| Alveolar ridge preservation with allograft | Active Comparator | Allograft |
|
| Alveolar ridge preservation with alloplast | Active Comparator | Beta Tri-Calcium phosphate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Toothgraft | Drug | Particulate dentin |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical assessment | Measure bone height loss in millimeter at baseline and after 3 months was measured using periodontal probe from the stent margin to the alveolar ridge crest at six points. In addition, Bone width loss was calculated by measuring alveolar ridge width buccopalatally in millimeter using a caliper clamp. The measurement was done perpendicular to the tangent of the dental arch at the mid-point of the extraction site approximately 4mm apical to the level of the marginal gingiva of the adjacent teeth. | 3 months |
| Clinical assessment | Bone width loss was calculated by measuring alveolar ridge width buccopalatally in millimeter using a caliper clamp. The measurement was done perpendicular to the tangent of the dental arch at the mid-point of the extraction site approximately 4mm apical to the level of the marginal gingiva of the adjacent teeth. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Radiographic assessment | Measuring loss in bone height in millimeters between baseline and after 3 months. Loss in bone height was calculated by measuring the distance from the alveolar crest both buccally and palatally to a fixed anatomical landmark. In addition, | 3 months |
| Radiographic assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Histological | Masson trichrome special stain was used to detect the area percentage of immature collagen and mature collagen at magnification 20X. The immature collagen appeared blue in color while areas with mature collagen appeared reddish in color | 3 months |
| Histomorphometric analysis |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yasmine A Fouad, Ph.D | Ain Shams University | Principal Investigator |
| Suzan M Sarhan, Ph.D | Ain Shams University | Study Director |
| Hadeel M Gamal, Ph.D | Ain Shams University | Study Director |
| Basma A Abdelrahman, Ph.D | Ain Shams University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | 11751 | Egypt |
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| ID | Term |
|---|---|
| D014184 | Transplantation, Homologous |
| ID | Term |
|---|---|
| D014180 | Transplantation |
| D013514 | Surgical Procedures, Operative |
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| Allograft |
| Drug |
Mineralized corticocancellous allograft |
|
|
| Alloplast | Drug | Beta tri-calcuim phosphate |
|
|
Loss in bone width was calculated by measuring distance from buccal alveolar crest to palatal alveolar crest in millimeter. |
| 3 months |
Photomicrographs of 3 microscopic fields of each MT stained section, were captured at the original magnification of 20X using a digital camera(Canon EOS 650D) mounted on a light microscope(BX60,Olympus , Japan). The images were analyzed for obtaining the area percentage of mature and immature collagen of the newly formed bone using image J (1.41aNIH, USA)software |
| 3 months |