Effect of Desflurane v/s Propofol on the Optic Nerve Shea... | NCT07359508

Studies
Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter

NCT07359508

Sponsor

All India Institute of Medical Sciences

Status

Completed

Last Update Posted

Jan 22, 2026Actual

Enrollment

146Actual

Phase

Phase 4

Conditions

Propofol Target-controlled Infusion
Desflurane
Optic Nerve Sheath Diameter

Interventions

Desflurane
Propofol (Group P)

Countries

India

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

ID	Type	Description	Link
AllMS	Other Identifier	AIIMS Raebareli

Status Module

Record Verification Date

Jan 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jan 10, 2024Actual

Primary Completion Date

Jun 15, 2025Actual

Completion Date

Jul 15, 2025Actual

First Submitted Date

Jan 14, 2026

First Submission Date that Met QC Criteria

Jan 14, 2026

First Posted Date

Jan 22, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jan 14, 2026

Last Update Posted Date

Jan 22, 2026Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

ADABALA VIJAY BABU, Vijay, All India Institute of Medical SciencesPrincipal Investigator

Lead Sponsor

All India Institute of Medical SciencesOTHER

Collaborators

Name	Class
All India Institute of Medical Sciences, Raebareli, UP	UNKNOWN

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

FDAAA801 Violation

Not provided

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Phase 4

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

146Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Propofol group	Experimental	propofol infusion will be given in this group after induction of the patient	Drug: Propofol (Group P)
Desflurane	Experimental	desflurane inhalation will be given in this group, after induction	Drug: Desflurane

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Desflurane	Drug	In the D group, anesthesia was maintained with oxygen/air (40:60), desflurane, fentanyl and vecuronium	Desflurane

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Optic nerve sheath diameter(ONSD)	ONSD will be measured in the operation thetaer	before induction, introperative period for every 10 minutes

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Patient aged 18-60 years ASA grade I or II scheduled for elective laparoscopic cholecystectomy

Exclusion Criteria:

patients with ophthalmological and cerebrovascular diseases, systemic infections, psychiatric disorders, pregnancy, Intracranial space occupying lesion, abnormal liver/kidney functions prior myocardial infarction.

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

60 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
AIIMS		Raebareli	Uttar Pradesh	229405	India

IPD Sharing Statement Module

Plan to Share IPD

Yes

Description

Not provided

Types

Study Protocol

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D000077335	Desflurane
D015742	Propofol

Ancestor Terms

ID	Term
D005019	Ethyl Ethers
D004987	Ethers
D009930	Organic Chemicals
D008738	Methyl Ethers

Browse Leaves

Not provided

Browse Branches

Not provided