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Intracranial pressure（ICP) increases during laparoscopic gynecologic surgery increase (ICP) and may alter optic nerve sheath diameter(ONSD).This study measures ONSD in different team because sevoflurane and propofol have different effects on ICP.Half of participants will receive sevoflurane anesthesia,while the other half undergo propofol anesthesia.
Due to the anatomical and physiological characteristics of optic nerve sheath ,ONSD increases when ICP rises.
Sevoflurane and propofol have different effects on ICP.When sevoflurane concentration >1.1 minimum alveolar concentration（MAC),ICP increases because of cerebral vasodilatation；on the other hand ,propofol constricts the blood vessels and ICP decreases.
ICP increases during laparoscopic gynecologic surgery because of steep Trendelenburg position and pneumoperitoneum .
Meanwhile,sevoflurane affects self regulation of cerebral blood flow on the way of dose dependent,but propofol has no effects on self regulation of cerebral blood flow.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Team Sevoflurane | Experimental |
| |
| Team Propofol | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane | Drug | In Team Sevoflurane,patients undergo sevoflurane. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of ultrasonographic optic nerve sheath diameter | different time including pre-anesthesia, after intubation,every 15 minutes in the first hour after beginning of surgery, every hour when one hour after surgery beginning,surgery ending. | from the time when patients enter into operation room to the time when the surgery ending |
| Measure | Description | Time Frame |
|---|---|---|
| Analyzed whether mean arterial pressure influence the change of ONSD based on 110 patients in two groups. | Mean arterial pressure was collected when measures ONSD by ultrasound. | from the time when patients enter into operation room to the time when the surgery ending |
| Analyzed whether airway pressure influence the change of ONSD based on 110 patients in two groups. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Obstetrics & Gynecology Hospital of Fudan University | Shanghai | Shanghai Municipality | 200090 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33504329 | Derived | Geng W, Chen C, Sun X, Huang S. Effects of sevoflurane and propofol on the optic nerve sheath diameter in patients undergoing laparoscopic gynecological surgery: a randomized controlled clinical studies. BMC Anesthesiol. 2021 Jan 27;21(1):30. doi: 10.1186/s12871-021-01243-7. |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| Propofol |
| Drug |
In Team Propofol ,anesthesia is maintained with propofol |
|
airway pressure was collected when measures ONSD by ultrasound. |
| from the time when patients enter into operation room to the time when the surgery ending |
| Analyzed whether urine volume influence the change of ONSD based on 110 patients in two groups. | Recording urine volume when the surgery finished. | from the time when patients enter into operation room to the time when the surgery ending |
| Analyzed whether blood loss influence the change of ONSD based on 110 patients in two groups. | Recording blood loss when the surgery finished. | from the time when patients enter into operation room to the time when the surgery ending |
| Analyzed whether fluid volume influence the change of ONSD based on 110 patients in two groups. | Recording fluid volume when the surgery finished. | from the time when patients enter into operation room to the time when the surgery ending |
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |